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Monotherapy with Carbon Ion Radiation for Localized Prostate Cancer

 RRecently the incidence of prostate cancer has been increasing in Japan, and more than half of the patients are organ-confined or in locally advanced stages. For these patients, radiation therapy is one of the curative strategy, and many radiological techniques are being used. Carbon ion radiation may be a powerful means of radiotherapy for prostate cancer, because it shows a Bragg peak in the human body and gives a high dose of radiation energy to the prostate without adverse effects to the surrounding tissues. The Heavy Ion Medical Accelerator in Chiba (HIMAC) was built at the National Institute of Radiological Sciences, and treatment was initiated with carbon ion radiation for many kinds of solid tumors (1,2). Treatment for prostate cancer by HIMAC started in 1995 and 400 patients have been treated to date. The patients were divided into either low-risk group [T1b,c and T2ab, Gleason score 6, and PSA (prostate-specific antigen) 20 ng/ml] or high-risk group.... See Full Article

Outcomes
Radiation Therapy for the Treatment of Unresected Stage I-II Non-small Cell Lung Cancer

Surgical resection is the most effective treatment for stage I and II non-small cell lung cancer, yet nearly 25% of these patients do not undergo surgery.Radiation therapy is generally used to treat these patients who, despite having resectable tumors, refuse surgery or have inoperable conditions due to medical reasons. The role of radiation therapy in the treatment of unresected stage I non-small cell lung carcinoma has been evaluated in several retrospective analyses and summarized in two reviews. For patients with unresected tumors, the prognosis is poor, with a 20% 5-year lung cancer survival rate (range, 13 to 39%). The majority of these studies, however, evaluated small numbers of patients, who often had been recruited from single tertiary...See Full Article

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